A ROS

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Many chemotherapy drugs for cancer increase levels of reactive oxygen species (ROS), but little is known about how these ROS impact cellular pathways. Reporting in Cell, Zhang et al. combine chemical proteomics and genomic screens to identify the ROS-regulated targets of several cancer drugs and reveal a druggable ROS-sensing pathway involved in chemoresistance.

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doi: https://doi.org/10.1038/d41573-023-00094-w

Zhang, J. et al. Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway. Cell 186, 2361–2379.e25 (2023)

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